The transition to the post-industrial phase of economic development and the construction of an information society within the framework of the digitalization of the economy are primarily associated with the provision of services through digital ecosystems and platforms. The widespread use of artifi cial intelligence (hereinafter referred to as AI) is currently observed in the implementation of entrepreneurial activities. Therefore, the assessment of the prospects for the employment of breakthrough, new technologies, including artifi cial intelligence, is becoming increasingly relevant and urgent, both in customs and business perspectives. Based on the research, the author has clarifi ed the concept of “artifi cial intelligence” (AI), namely, artifi cial intelligence should be understood as the ability of a digital computer algorithm to perform specifi c tasks usually associated with the life of intelligent beings (humans). The study has revealed the positive and negative consequences of applying artifi cial intelligence. Building on the analysis of the accumulated experience in the use of artifi cial intelligence algorithms within the framework of the current customs regulation in the Russian Federation, the paper has identifi ed the most promising areas of applying artifi cial intelligence in the fi eld of regulation of foreign economic activity, in interdepartmental interaction within the framework of customs operations.